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. Author manuscript; available in PMC: 2024 Apr 1.
Published in final edited form as: J Invest Dermatol. 2022 Oct 8;143(4):639–647.e2. doi: 10.1016/j.jid.2022.09.007

Figure 2: HSV-1 causes larger lesions in Peli1−/− mice.

Figure 2:

Wild type and Pellino-1 KO mice were infected with HSV-1. (a), Timing and progression of HSV infection in the mouse flank model is illustrated. (b), Lesions on the flanks were photographed up to day 9 and sized using ImageJ. Representative data and images from one of at least 3 independent experiments (n = 4-5 per group) is shown. Each dot represents a single mouse. *, p < 0.05; **, p < 0.01 (t test), (c), Skin area with early zosteriform sites above and below the primary infection site were collected 5 days post-primary infection and histology evaluated alongside uninfected skin by H&E staining. Scale bar = 1 mm. Blue and magenta arrows mark regions with absent and detaching epidermis, respectively.