Figure 2. Basal firing properties of LC neurons from 6- and 15-month TgF344-AD rats and WT littermates.
A) Baseline firing was lower in TgF344-AD rats at both ages. B) There was a trend towards decreased interspike interval in TgF344-AD rats. C) Firing rate during spontaneous bursts was higher in TgF344-AD rats. D) Interspike intervals within a burst were lower in TgF344-AD rats, and there was an additional effect of age where younger rats had lower interspike intervals. N=74–120 neurons/group (N=8–11 animals/group) for A and B. N=48–88 neurons/group (N=8–11 animals/group) for C and D. *p<0.05, **p<0.01.