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. Author manuscript; available in PMC: 2024 May 1.
Published in final edited form as: J Steroid Biochem Mol Biol. 2023 Jan 18;229:106254. doi: 10.1016/j.jsbmb.2023.106254

Figure 1.

Figure 1.

Cellular immune responses altered by progesterone signaling in the decidua. During pregnancy, progesterone favors natural killer (NK)-cell activity that is necessary for successful remodeling and angiogenesis in this tissue. This hormone then fosters a local tolerogenic microenvironment by promoting regulatory T cells, γδ T cells, and B cells as well as controlling the maturation of decidual dendritic cells (DCs). On the other hand, progesterone limits the migration and functions of conventional T cells, cytotoxic NK cells, neutrophils, and macrophages to further maintain decidual homeostasis. Created with BioRender.com.