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. 2023 Mar 24;9:32. doi: 10.1038/s41421-023-00533-3

Fig. 9. Schematic model of calpain regulation by the Cullin-3–RBX1–KCTD7 complex.

Fig. 9

Shown is a comparison between WT conditions and deficiency of KCTD7 leading to calpain dysregulation and activation of a pathogenic cascade.