Table 1.
COV434 | TOV-112D | ||||
---|---|---|---|---|---|
Antibody | Staining | Slide | Well differentiated | Undifferentiated | Slide |
SMARCA4 | Negative | Whole | Positive | Negative | Whole |
SMARCA2 | Negative | Whole | Positive | Negative | Whole |
SMARCB1 | Positive | Whole | Positive | Positive | Whole |
WT1 | Positive | Whole | Negative | Negative | Whole |
p53 | Wild type | Whole# | Missense mutant | Missense mutant | Whole |
FOXL2 | Negative | Whole | Negative | Negative | TMA |
Inhibin A | Negative | Whole | Negative | Negative | TMA |
Calretinin | ND | Negative | Negative | TMA | |
MMR proteins## | Intact | Whole | Intact | Intact | TMA |
AE1/AE3 | ND | Positive | Negative | Whole | |
MOC31 | ND | Positive | Negative | TMA | |
Claudin-4 | ND | Positive | Negative | TMA | |
EMA | ND | Positive, patchy | Negative | TMA | |
PAX8 | ND | Negative | Negative | TMA | |
p16 | ND | Negative | Diffuse strong | Whole | |
ER | ND | Positive | Negative | Whole | |
PR | ND | Positive | Negative | Whole | |
Napsin A | ND | Negative | Negative | Whole | |
HNF1 beta | ND | Negative | Negative | Whole | |
ARID1A | ND | Positive | Positive | Whole | |
PTEN | ND | Positive | Positive | Whole | |
CD10 | Negative | Whole | ND | ND | |
synaptophysin | Negative | Whole | ND | ND | |
chromogranin | Negative | Whole | ND | ND | |
CD56 | Negative | Whole | ND | ND |
Notes:
, staining was done on whole slides of cell line xenografted tumour;
, mismatch repair (MMR) proteins include MLH1, MSH2, MSH6 and PMS2; ND, not determined.