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. Author manuscript; available in PMC: 2023 Mar 25.
Published in final edited form as: Oncogene. 2022 May 16;41(25):3423–3432. doi: 10.1038/s41388-022-02348-0

Fig. 5. Heatmap of NRF2 target gene expression in human neuroendocrine lung tumors.

Fig. 5

Gene expression, histopathology, and tumor mutation data were mined from a previous meta-analysis of lung tumors. Gene expression data for NRF2 target genes were VST-normalized and median-centered, and hierarchically clustered separately within each tumor super-class. Sex, histopathological classifications, molecular clusters, and mutations in KEAP1/NRF2 are designated in colors at the top based on previous annotations. Higher expression values are designated in red, and lower expression values are designated in blue. Tumors carrying KEAP1/NRF2 tumors are designated in black.