Table 1.
Sample Demographics for Caribbean-Hispanic and Non-Hispanic White RNAseq Samples.
| Sample | Non-LOAD | LOAD | P-value |
|---|---|---|---|
|
| |||
| CH | (n = 16) | (n = 23) | |
| sex (M/F) | 8 M, 8F | 7M, 16F | 0.32 |
| age | 66.9 (11.8) | 79 (10.9) | 0.0026 |
| RIN | 5.8 (1.5) | 4.2 (1.5) | 0.0024 |
| PSEN1 carriers (+/−) | 16− | 5+/18− | 0.07 |
| Library size, millions | 16.2 (4.1) | 15.6 (3.8) | 0.65 |
| ROS/MAP (NHW) | (n = 229) | (n = 354) | |
| sex (M/F) | 88 M, 141F | 113 M, 241F | 0.11 |
| age | 87 (7.2) | 90.1 (5.9) | 7.7 × 10−8 |
| RIN | 7.2 (1.1) | 7 (0.9) | 0.015 |
| PMI | 7.1 (4.1) | 7.6 (5.2) | 0.18 |
| Library size, millions | 30.1 (13.5) | 26.5 (8.8) | 4.9 × 10−4 |
| Mayo (NHW) | (n = 68) | (n = 80) | |
| sex (M/F) | 33 M, 35F | 31 M, 49F | 0.25 |
| age | 82.9 (8.4) | 82.6 (7.7) | 0.84 |
| RIN | 7.6 (1) | 8.6 (0.6) | 1.4 × 10−9 |
| PMI | 6.5 (6.5) | 6.7 (4.3) | 0.84 |
| Library size, millions | 40.9 (11.1) | 45.4 (10) | 0.013 |
Note:
*
p-values correspond to those from two-sided, two-sample t-tests for continuous measures (age, RIN, library size, and PMI) and from two-sided Fisher’s exact tests for dichotomous measures (sex and PSEN1 G206A mutation status).
Summary measures for continuous outcomes are means (standard deviations in brackets). RIN = RNA integrity number; LOAD = late-onset Alzheimer’s disease; M = male; F = female; PMI = postmortem interval; CH = Caribbean-Hispanic (all genetically-confirmed, three-way admixed subjects); NHW = non-Hispanic white; ROS/MAP = Religious Orders Study / Memory and Aging Project; PMI = postmortem interval.