Table 1.
Patients’ clinical characteristics
|
|
|
All subjects
|
Stronger postoperative analgesia with tramadol/paracetamol
|
Weaker postoperative analgesia with tramadol/paracetamol
|
|---|---|---|---|---|
|
Sample size
|
|
N = 113
|
N = 55
|
N = 58
|
| Characteristic | N (%) | N (%) | N (%) | |
| Age (years) | Median (25–75 %) | 55 (48–63) | 57 (49–64) | 53,5 (47.8–61) |
| Weight (kg) | Median (25–75 %) | 72 (63.5–82) | 72 (64–82) | 72 (63–82.3) |
| Body Mass Index (kg/m2) | Median (25–75 %) | 27.1 (23.4–31.0) | 26.7 (23.0–30.8) | 27.6 (23.5–31.2) |
| Smoking | No | 87 (77.7) [1] | 41 (75.9) [1] | 46 (79.3) |
| Yes | 25 (22.3) | 13 (24.1) | 12 (20.7) | |
| ASA score | 1 | 22 (19.6) [1] | 10 (18.2) | 12 (21.1) [1] |
| 2 | 81 (72.3) | 39 (70.9) | 42 (73.7) | |
| 3 | 9 (8.0) | 6 (10.9) | 3 (5.3) | |
| Side of the operation | Left | 62 (54.9) | 30 (54.5) | 32 (55.2) |
| Right | 50 (44.2) | 24 (43.6) | 26 (44.8) | |
| Bilateral | 1 (0.9) | 1 (1.8) | 0 (0.0) | |
| Tumor grade | 1 | 4 (3.6) [1] | 1 (1.9) [1] | 3 (5.2) |
| 1–2 | 3 (2.7) | 2 (3.7) | 1 (1.7) | |
| 2 | 39 (34.8) | 17 (31.5) | 22 (37.9) | |
| 2–3 | 8 (7.1) | 2 (3.7) | 6 (10.3) | |
| 3 | 58 (51.3) | 32 (59.3) | 26 (44.8) | |
| VAS after 7 days | Median (25–75 %) | 2 (1–3) [5] | 1.3 (1–2) [3] | 2 (1–3) [2] |
| VAS after 14 days | Median (25–75 %) | 1.5 (0–2) [11] | 1 (0–2) [9] | 2 (1–2) [2] |
| VAS after 21 days | Median (25–75 %) | 1 (0.4–2) [11] | 1 (0–2) [9] | 1 (1–2) [2] |
| VAS after 28 days | Median (25–75 %) | 1 (0–2) [14] | 1 (0–1) [10] | 1 (1–2) [4] |
ASA = American Society of Anaesthesiology; N = sample size; [n] = number of missing data; VAS = visual analog scale
Genotype frequencies, MAF, and Hardy-Weinberg equilibrium analysis (PHWE) of investigated polymorphisms in all patients enrolled in our study are presented in Table 2.