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. 2023 Mar 21;17:851–861. doi: 10.2147/DDDT.S402362

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© 2023 Alshehri.

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Suggested tapentadol analgesic mechanism of action. A dual-function on the mu-opioids receptor (MOR) and norepinephrine reuptake transporter (NET). Alpha 2- adrenoreceptor (A2-AR), substance P receptor (SPR), and Glutamate receptor (GLR).