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. 2023 Mar 25;22:61. doi: 10.1186/s12943-023-01766-2

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Biological functions of circRNAs in bladder cancer (BCa)

(A) CircRNAs are involved in the cell proliferation and cycle of BCa. CircSETD3, circ0068307, circ0030586, and circ0041103 affect the cell proliferation of BCa cells by regulating the expression of miRNAs and related proteins. (B) CircRNAs are involved in the metastasis and EMT of BCa. CircTRPS1, circKDM4C, circITCH, and circACVR2A affect the cell metastasis and EMT of BCa cells by regulating the expression of miRNAs and related proteins. (C) CircRNAs are involved in the apoptosis of BCa. CircCEP128, circ001418, circ0058063, and circ0000326 affect the cell apoptosis of BCa cells by regulating the expression of miRNAs and related proteins. (D) CircRNAs are involved in the drug resistance of BCa. Circ102336, circ0008399, and circ0058063 affect the drug resistance of BCa cells by regulating the expression of miRNAs and related proteins