Table 2.
Overview of deregulated circRNAs in renal cell carcinoma
| CircRNA | Expression | Function | Target microRNA | miRNA target genes/protein | Ref |
|---|---|---|---|---|---|
| Circ000926 | Up |
Proliferation(+) Metastasis(+) |
miR-411 | CDH2 | [106] |
| CircEGLN3 | Up |
Proliferation(+) Metastasis(+) |
miR-1224-3p | HMGXB3 | [107] |
| CircRAPGEF5 | Down |
Proliferation(-) Metastasis(-) |
miR-27a-3p | TXNIP | [115] |
| Circ0001368 | Down |
Proliferation(-) Metastasis(-) |
miR-492 | LATS2 | [116] |
| Circ0054537 | Up |
Proliferation(+) Metastasis(+) Apoptosis(−) |
miR- 130a-3p | cMet | [122] |
| CircSCARB1 | Up |
Proliferation(+) Metastasis(+) Apoptosis(−) |
miR-510-5p | SDC3 | [108] |
| CircUBAP2 | Down |
Proliferation(-) Metastasis(-) |
miR-148a-3p | FOXK2 | [117] |
| CircMTO1 | Down |
Proliferation(-) Metastasis(-) |
miR-9 | LMX1A | [109] |
| CircAKT3 | Down | Metastasis(-) | miR-296-3p | E-cadherin | [118] |
| CircTLK1 | Up |
Proliferation(+) Metastasis(+) |
miR-136-5p | CBX4 | [110] |
| CircSDHC | Up |
Proliferation(+) Metastasis(+) |
miR-127-3p | CDKN3/E2F1 | [111] |
| CircCHST15 | Up |
Proliferation(+) Metastasis(+) |
miR-125a-5p | EIF4EBP1 | [112] |
| CircESRP1 | Down |
Proliferation(-) Metastasis(-) |
miR-3942 | CTCF | [119] |
| Circ0005875 | Up |
Proliferation(+) Metastasis(+) Apoptosis(−) |
miR-502-5p | ETS1 | [123] |
| Circ0035483 | Up |
Proliferation(+) Metastasis(+) |
miR-31-5p | HMGA1 | [127] |
| CircDVL1 | Down |
Proliferation(-) Metastasis(-) Apoptosis(+) |
miR-412-3p | PCDH7 | [113] |
| CircEGLN3 | Up |
Proliferation(+) Metastasis(+) Apoptosis(−) |
miR-1299 | IRF7 | [124] |
| CircMYLK | Up |
Proliferation(+) Metastasis(+) |
miR-513a-5p | VEGFC | [120] |
| Circ001842 | Up |
Proliferation(+) Metastasis(+) Apoptosis(−) |
miR-502-5p | SLC39A14 | [125] |
| CircNUP98 | Up |
Proliferation(+) Metastasis(+) Apoptosis(−) |
miR-567 | PRDX3 | [126] |
| CircFOXP1 | Up |
Proliferation(+) Metastasis(+) |
miR-423-5p | U2AF2 | [128] |
| CircPSD3 | Down |
Proliferation(-) Metastasis(-) |
miR-25-3p | FBXW7 | [114] |
| CircTXNDC11 | Up | Metastasis(+) | - | MAPK/ERK | [121] |
| Circ0054537 | UP |
Glycolysis(+) Apoptosis(−) |
miR-640 | NPTX2 | [129] |