Table 3.
Overview of deregulated circRNAs in bladder cancer
| CircRNA | Expression | Function | Target microRNA | miRNA target genes/protein | Ref |
|---|---|---|---|---|---|
| Circ0030586 | Down | Proliferation(-) | miR-665 | NR4A3 | [131] |
| Circ102336 | Up |
Proliferation(+) Resistance(-) |
miR-515-5p | - | [153] |
| CircTRPS1 | Up |
Proliferation(+) Metastasis(+) |
miR-141-3p | GLS1 | [130] |
| Circ001418 | Up |
Proliferation(+) Metastasis(+) Apoptosis(−) |
miR-1297 | EphA2 | [148] |
| Circ0091017 | Up |
Proliferation(+) Metastasis(+) |
miR-589-5p | - | [132] |
| Circ0041103 | Up |
Proliferation(+) Metastasis(+) |
miR-107 | FOXK1 | [133] |
| Circ0058063 | Up |
Proliferation(+) Apoptosis(−) Resistance(−) |
miR-335-5p | B2M | [155] |
| Circ0068307 | Up |
Proliferation(+) Metastasis(+) |
miR-147 | c-Myc | [134] |
| CircITCH | Down |
Proliferation(-) Metastasis(-) Apoptosis(+) |
miR-17/ miR-224 | p21/ PTEN | [140] |
| CircACVR2A | Down |
Proliferation(-) Metastasis(-) |
miR-626 | EYA4 | [141] |
| Circ0068871 | Up |
Proliferation(+) Metastasis(+) Apoptosis(−) |
miR-181a-5p | STAT3 | [142] |
| Circ0008532 | Up | Metastasis(+) | miR-155-5p /miR-330-5p | MTGR1 | [143] |
| Circ0001944 | Up |
Proliferation(+) Metastasis(+) |
miR-548 | PROK2 | [135] |
| Circ0000658 | Up | Metastasis(+) | miR-498 | HMGA2 | [144] |
| Circ0023642 | Up | Metastasis(+) | miR-490-5p | EGFR | [145] |
| CircST6GALNAC6 | Down |
Proliferation(-) Metastasis(-) |
miR-200a-3p | STMN1 | [146] |
| CircUBE2K | Up |
Proliferation(+) Metastasis(+) |
miR-516b-5p | ARHGAP5 | [136] |
| CircKDM4C | Up | Metastasis(+) | miR-200bc-3p | ZEB1 | [147] |
| Circ0058063 | Up |
Metastasis(+) Apoptosis(−) |
miR-486-3p | FOXP4 | [149] |
| Circ100984 | Up |
Proliferation(+) Metastasis(+) |
miR-432-3p | c-Jun/YBX-1/β-catenin | [137] |
| CircSETD3 | Down |
Proliferation(-) Metastasis(-) |
miR-641 | PTEN | [138] |
| Circ0006948 | Up |
Proliferation(+) Metastasis(+) |
- | N-cadherin | [139] |
| Circ0000629 | Down |
Proliferation(-) Metastasis(-) Apoptosis(+) |
miR-1290 | CDC73 | [150] |
| CircCEP128 | Up |
Proliferation(+) Metastasis(+) Apoptosis(−) |
miR-145-5p | MYD88 | [151] |
| Circ0000326 | Up |
Proliferation(+) Metastasis(+) Apoptosis(−) |
miR-338-3p | ETS1 | [152] |
| Circ0008399 | Up | Resistance(+) | - | WTAP | [154] |