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. Author manuscript; available in PMC: 2024 Mar 8.
Published in final edited form as: Cell Host Microbe. 2023 Mar 8;31(3):389–404.e7. doi: 10.1016/j.chom.2023.02.001

Figure 7. Kupffer cells mediate the disease exacerbating effect of adoptively transferred polyclonal C. albicans-primed T cells.

Figure 7.

(A) Diagram of adoptive transfer of polyclonal C. albicans-primed T cells to mice lacking IL17ra on Kupffer cells (II17raΔKC) and their littermate II17rafl/fl mice. II17raΔKC and littermate II17rafl/fl mice were fed a chronic plus binge ethanol diet and injected C. albicans-primed polyclonal T cells intravenously 3 days before harvesting. (B) Serum levels of ALT. (C) Hepatic triglyceride content. (D) Representative oil red O-stained liver sections (scale bar, 100 μm). (E) Hepatic levels of Il1b mRNA. (F) Serum levels of ethanol. (G and H) Hepatic levels of Cyp2e1 and Adh1 mRNAs. Figure 7 was conducted in 2 independent experiments. Results are expressed as mean±SEM. P values determined by 2-sided Student t test. *P<0.05, **P<0.01. See also Figure S6 and Figure S7.