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. 2023 Mar 22;43(12):2075–2089. doi: 10.1523/JNEUROSCI.1273-22.2023

Figure 4.

Figure 4.

Cochlear function at 1 and 30 d after exposure to PTS-imparting 93 dB SPL noise level in the presence, absence, or repopulated macrophages. A, ABR threshold shifts at 1 and 30 DPNE at 93 dB SPL (8-16 kHz) for 2 h. Control chow (n = 6 mice), PLX5622 chow (n = 9 mice), and PLX5622 chow replaced with control chow (n = 9 mice). *Comparison between 1 and 30 DPNE: **p < 0.01; ****p < 0.0001; respective stimulus frequencies. #Comparison between 30 DPNE and 45 d sham-exposed: #p < 0.05; ##p < 0.01; ####p < 0.0001; two-way ANOVA, Sidak's multiple comparisons test. For 45 d on chow sham exposure, ABR threshold shifts, control chow (n = 3 mice), PLX5622 chow (n = 4 mice), and PLX5622 chow replaced with control chow (n = 3 mice). Dashed line indicates threshold shifts at baseline (prenoise exposure). Dotted line indicates threshold shifts at baseline (prenoise exposure). B, DPOAE levels at baseline (prechow), 1 DPNE, 30 DPNE at 93 dB SPL (8-16 kHz) for 2 h and of age-matched sham-exposed mice after 45 d fed on control chow (n = 6 mice), PLX5622 chow (n = 9 mice), and PLX5622 chow replaced with control chow (n = 9 mice) chows. For 45 d on chow sham exposure, DPOAE levels, control chow (n = 3 mice), PLX5622 chow (n = 4 mice), and PLX5622 chow replaced with control chow (n = 3 mice). Black line indicates noise floor. Data are mean ± SD. ns, not significant.