TABLE 3.
Adjusted hazard ratios (MC) for CD patients versus reference individuals and siblings.
| CD compared to reference individuals | CD compared to siblings | |
|---|---|---|
| Adjusted hazard ratio | Adjusted hazard ratio | |
| Total number of events/1000 person‐years | 11.6 [9.8–13.8] | 6.2 [4.7–8.2] |
| Sex | ||
| Males | 12.7 [9.2–17.7] | 9.6 [4.3–21.2] |
| Females | 11.2 [9.2–13.7] | 4.9 [3.3–7.3] |
| Excluding MC diagnosed within 1 year of CD | 9.8 [8.2–11.8] | 4.9 [3.7–6.6] |
| Age at start follow up (years) | ||
| <18 | 24.3 [11.2–52.6] | 12.4 [1.4–108.9] |
| 18 < 40 | 15.9 [10.8–23.5] | 18.9 [7.3–48.9] |
| 40 < 60 | 11.0 [8.4–14.4] | 5.5 [3.5–8.6] |
| ≥60 | 8.9 [6.7–11.8] | 17.5 [5.4–56.0] |
| Follow up (years) | ||
| <1 | 35.2 [20.1–61.6] | 5.7 [4.4–7.5] |
| 1 < 5 | 15.1 [10.6–21.5] | 7.0 [4.1–12.2] |
| 5 < 10 | 7.9 [5.6–10.9] | 5.3 [2.8–10.0] |
| ≥10 | 8.1 [6.0–10.9] | 4.4 [2.7–7.0] |
| Year of start follow up | ||
| 1990–2000 | 8.7 [6.8–11.1] | 5.4 [3.5–8.3] |
| 2001–2010 | 12.9 [10.1–16.9] | 7.4 [4.8–11.3] |
| 2011–2016 | 26.7 [14.0–50.9] | 15.9 [4.5–55.8] |
| Year of start follow up (with max 3 years of follow up) | ||
| 1990–2000 | 35.4 [ 12.4–101.2] | 59.5 [1.7–2096.2] |
| 2001–2010 | 25.9 [16.0–41.9] | 14.3 [5.9–34.7] |
| 2011–2013 | 25.4 [11.9–54.4] | 39.2 [4.6–333.7] |
| Country of birth | ||
| Nordic | 11.1 [9.3–13.2] | 6.1 [4.7–8.1] |
| Other | NA a | NA a |
| Education | ||
| Compulsory school (<9 years) | 10.6 [6.9–16.3] | 12.6 [4.0–39.4] |
| Upper secondary school (10–12 years) | 9.2 [6.6–12.8] | 8.5 [4.2–17.3] |
| College or university (≥13 years) | 15.0 [8.9–25.3] | 11.1 [3.9–31.2] |
| Missing | NA b | NA c |
| Comorbidity | ||
| Diabetes | 0.44 [0.04–5.4] | NA a |
| No diabetes | 11.0 [10.0–14.3] | 6.3 [4.8–8.4] |
| Inflammatory bowel disease | NA d | NA d |
| No inflammatory bowel disease | 11.7 [9.9–14.0] | 6.5 [4.9–8.7] |
| Thyroid disease | NA d | NA a |
| No thyroid disease | 11.7 [9.9–13.9] | 6.3 [4.8–8.4] |
| Rheumatoid arthritis | NA d | NA d |
| No rheumatoid arthritis | 11.9 [10.0–14.1] | 6.4 [4.8–8.4] |
Note: Adjusted for sex, age, calendar period, county, education, RA, diabetes, thyroid disease, IBD.
Abbreviations: CD, celiac disease; IBD, inflammatory bowel disease; MC, microscopic colitis; RA, rheumatoid arthritis.
a
MC only occurred among the exposed.
b
MC only occurred among the reference population.
c
No events of MC within the same family specific stratum.
d
No events of MC recorded.