TABLE 2.
Summary of the principal studies considering liver transplant (LT) as an option for alcohol‐related liver disease (ArLD) cirrhosis (A) and acute alcoholic hepatitis (AAH) (B) according to sex.
| Author (year) | Country | N of women versus men on wait list (%) | N of women versus men underwent LT (%) | Survival of women versus men | Graft loss women versus men | Relapse women versus men |
|---|---|---|---|---|---|---|
| (A) | ||||||
| Askgaard et al. (2016) | Denmark | No data reported | 28 (18%) versus 128 (82%) | No data reported according to sex | No data reported according to sex | 10 (35%) versus 25 (19%) |
| Relative risk: Women 1.2 (0.6; 2.5) versus men 1 (0.7; 0.9); p = 0.6 | ||||||
| Wigg et al. (2017) | Australia | No data reported | 14 (16%) versus 73 (84%) | No data reported according to sex | No data reported according to sex | Harmful relapse: 2 (14%) versus 12 (16%) |
| Weeks et al. (2018) | USA | No data reported | 12 (35%) versus 22 (65%) | No data reported according to sex | No data reported according to sex | 4 (33%) versus 4 (22%) |
| Legaz et al. (2019) | Spain | No data reported | 32 (9%) versus 368 (81%) | 23 (72%) versus 255 (69%) at 10 years follow up (p = 0.89) | 1 (11%) versus 22 (19%) | No data reported |
| Matsuoka et al. (2020) | USA | No data reported | 2857 (21%) versus 10,924 (79%) | No difference in patient survival according to sex (p = 0.197) | No difference in graft survival according to sex (p = 0.066) | No data reported |
| McElroy et al. (2020) | USA | 33 (21%) versus 121 (79%) | 14 (19%) versus 57 (81%) | No data reported according to sex | No data reported according to sex | No data reported according to sex |
| Lee et al. (2021) | USA | No data reported | 2782 (22%) versus 9502 (88%) | Women aged <40 years had lower adjusted 5 years mortality versus women aged >40 years and versus men | No data reported | Age <40 years: Women 32% died for alcohol relapse versus male 25% |
| Louvet et al. (2022) | France and Belgium | 128 patients | 25 (27%) versus 68 (73%) | 81 (63% of total); No data reported according to sex | No data reported according to sex | 23 (25% of total) No data reported according to sex |
| (B) | ||||||
| Im et al. (2016) | USA | 9 (45%) versus 11 (65%) | 4 (44%) versus 5 (66%) | 4/4 (100%) versus 4/5 (80%) | No graft loss | 1 (25%) versus 0 (0%) |
| Lee et al. (2018) | USA | No data reported according to sex | 42 (27%) versus 105 (73%) | Sex female not associated with increased risk of death 1.16 (0.43–3.08) p = 0.77 | No data reported according to sex | Sex female not associated with increased risk of relapse |
| 1.32 (0.60–2.92) 0.49 | ||||||
| Week et al. (2018) | USA | No data reported according to sex | 13 (28%) versus 33 (72%) | No data reported according to sex | No data reported according to sex | 4 (30%) versus 9 (27%) |
| Germani et al. (2022) | Italy | 20 patients; No data reported according to sex | 5 (31%) versus 11 (69%) | 15 survived. No data reported according to sex | No data reported according to sex | 2 alcohol relapse (32%); No data reported according to sex |
| Louvet et al. (2022) | France and Belgium | 102 patients; No data reported according to sex | 22 (32%) versus 46 (68%) | 61 patients survived. No data reported according to sex | No data reported according to sex | 23 alcohol relapses (34% of total). No data reported according to sex |