FIGURE 4.

Humanization of gut microbial genera in captive NHPs is reproducible and host-species specific. Plots show relationships of microbial genus-level Host Specificity Scores (HSSs) between pairs of captive NHP populations. Each point represents the HSSs of a bacterial genus in two captive NHP populations (rows and columns), and lines indicate best-fit linear regressions. Cartoons represent NHP species and are coloured as in Figure 1. Tree connecting cartoons shows phylogenetic relationships among NHPs. Rows and columns correspond to NHP species, with each plot showing a regression between HSSs for a pair of NHP species. Boxes are coloured based on R² of regression, with R² > .8 coloured dark red, 0.8 > R² > .1 coloured light red, and R² < .1 coloured grey. R², Spearman’s rho, and corresponding p-values are reported in the top left corner of each plot. Significance for nonzero slope of regression line (based on Pearson’s correlation) is indicated in the bottom right corner of each plot; NS, not significant; *p < 0.05; ** p < .01; ***p < .001