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. 2023 Jan 19;60(5):2426–2441. doi: 10.1007/s12035-023-03224-y

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Overexpression of miR-650 decreases CDK5 levels in vivo. A The dentate gyrus (DG) of APP-PSEN1 mice was injected bilaterally with adeno-associated virus (AAV) vectors: AAV-GFP control virus was injected in the left DG and AAV-miR-650 virus in the right DG (n = 3). B Expression of miR-650 was only seen in the hippocampus sections that were injected with AAV-miR-650 (unpaired t-test, p < 0.01). C–D Western blot analysis shows a significant decrease in CDK5 levels on hippocampus samples injected with AAV-miR-650 (unpaired t-test, p < 0.01). E Transcript levels of CDK5 were also significantly decreased in the samples injected with AAV-miR-650 (unpaired t-test, p < 0.01)