Fig. 3. Molecular characteristics of mesenchymal neoplasms with DICER1 alteration.

DICER1 variants identified in a LGMT DICER1, b SARC DICER1 and c PIS DICER1. d Genomic index (total number of segmental gains or losses²/number of involved chromosomes) of LGMT DICER1, SARC DICER1 and PIS DICER1, indicative of genomic complexity (n = 86). Black lines mark the median, edges of boxes denote interquartile range (IQR), and vertical lines indicate 1.5 × IQR. Statistical significance was determined by the Games-Howell post-hoc test. e Case-by-case copy number profiles of LGMT DICER1, SARC DICER1 and PIS DICER1 with chromosomal gains depicted in red and losses shown in blue. f Variants called by panel-based DNA sequencing of 80 tumors from the three classes of mesenchymal neoplasms with DICER1 alteration. Above DNA sequencing results, patients age, gender, tumor location, institutional diagnoses and DNA methylation class assignment are annotated as indicated by the figure’s legend.