Skip to main content
. 2023 Mar 25;14:1677. doi: 10.1038/s41467-023-37092-w

Fig. 5. Characteristics of DNA methylation outlier in clusters of mesenchymal neoplasms with DICER1 alteration.

Fig. 5

a DICER1 variants and chromosome 8 copy number status of 9 thyroid, uterine and ovarian tumors, that clustered with LGMT DICER1 or SARC DICER1 in DNA methylation analysis (Fig. 1a). Above outlier ID, DNA methylation class assignment, gender, tumor location and institutional diagnoses are annotated as indicated by the figure’s legend. b–e Limited histomorphological evaluation of individual outliers diagnosed as MAS, MAS/ERMS or SLCT revealed (d) rhabdomyosarcomatous differentiation in a subset (n = 2) of tumors. Hematoxylin & Eosin, scale bar equals 100 μm. Cumulative copy number profiles of molecular classes of f MG, g MAS and h SLCT DICER1 showing the frequency of any chromosomal aberration at the respective loci (related to Supplementary Fig. 2). Chromosomal gains are depicted in red, and losses shown in blue.