Table 3.

Significant associations (FDR p<0.05) from the primary analysis between fractional anisotropy and scores on the attention problems scale and/or ADHD diagnosis. Also shown are the results of the sensitivity analyses examining the robustness of the association for these tracts. Results are summarized for all tracts and models in the Supplementary Results.

Independent variable	Model	N	Β	SE	t	Uncorrected p	FDR-p	Effect size: partial-r or cohen’s d (95% confidence interval).
Left inferior longitudinal fasciculus
Primary analysis	Attention problems scale	6904	−0.0002	0.00007	−3.53	0.0004	0.02	−0.12 (−0.19 to −0.05)
Stringent QC threshold (worst 20% of subjects on any motion parameter excluded)	Attention problems scale	5453	−0.0002	0.00008	−2.94	0.003	-	−0.12 (−0.2 to −0.04)
Matched on covariates including QC variables	Attention problems scale	6096	−0.0002	0.00007	−3.13	0.002	-	−0.12 (−0.19 to −0.04)
Controlling for IQ	Attention problems scale	6904	−0.0002	0.00007	−3.28	0.001	-	−0.11 (−0.18 to −0.05)
Excluding subjects with possible bipolar and/or psychosis symptoms	Attention problems scale	6473	−0.0003	0.00008	−3.91	0.0001	-	−0.14 (−0.21 to −0.07)
CBCL scores adjusted for medication status	Attention problems scale	6904	−0.0002	0.00006	−3.58	0.0004	-	−0.12 (−0.19 to −0.06)
Primary analysis	ADHD diagnosis	5811	−0.003	0.0008	−3.43	0.0006	0.048	−0.27 (−0.42 to −0.11)
Stringent QC threshold (worst 20% of subjects on any motion parameter excluded)	ADHD diagnosis	4665	−0.003	0.0009	−2.95	0.003	-	−0.26 (−0.44 to −0.09)
Matched on covariates including QC variables	ADHD diagnosis	2084	−0.003	0.001	−2.61	0.01	-	−0.52 (−0.92 to −0.12)
Controlling for IQ	ADHD diagnosis	5811	−0.003	0.0008	−3.2	0.001	-	−0.25 (−0.4 to −0.1)
Excluding subjects with possible bipolar and/or psychosis symptoms	ADHD diagnosis	5504	−0.003	0.0009	−3.51	0.0005	-	−0.28 (−0.44 to −0.12)
Left uncinate fasciculus
Primary analysis	Attention problems scale	6911	−0.0003	0.00008	−4.13	0.00004	0.02	−0.14 (−0.21 to −0.07)
Stringent QC threshold (worst 20% of subjects on any motion parameter excluded)	Attention problems scale	5454	−0.0003	0.00009	−3.41	0.0007	-	−0.14 (−0.21 to −0.06)
Matched on covariates including QC variables	Attention problems scale	6104	−0.0003	0.00008	−3.39	0.0007	-	−0.13 (−0.2 to −0.05)
Controlling for IQ	Attention problems scale	6911	−0.0003	0.00008	−3.88	0.0001	-	−0.13 (−0.2 to −0.07)
Excluding subjects with possible bipolar and/or psychosis symptoms	Attention problems scale	6478	−0.0004	0.00009	−4.26	0.00002	-	−0.15 (−0.22 to −0.08)
CBCL scores adjusted for medication status	Attention problems scale	6911	−0.0003	0.00007	−4.18	0.00003	-	−0.14 (−0.21 to −0.08)
Primary analysis	ADHD diagnosis	5816	−0.003	0.0009	−3.85	0.0001	0.02	−0.3 (−0.45 to −0.15)
Stringent QC threshold (worst 20% of subjects on any motion parameter excluded)	ADHD diagnosis	4665	−0.003	0.001	−3.09	0.002	-	−0.28 (−0.45 to −0.1)
Matched on covariates including QC variables	ADHD diagnosis	2091	−0.003	0.001	−2.40	0.02	-	−0.48 (−0.88 to −0.08)
Controlling for IQ	ADHD diagnosis	5816	−0.003	0.0009	−3.65	0.0003	-	−0.28 (−0.44 to −0.13)
Excluding subjects with possible bipolar and/or psychosis symptoms	ADHD diagnosis	5509	−0.004	0.001	−3.96	0.00008	-	−0.32 (−0.48 to −0.16)
Right inferior longitudinal fasciculus
Primary analysis	ADHD diagnosis	5814	−0.003	0.0009	−3.49	0.0005	0.048	−0.27 (−0.42 to −0.12)
Stringent QC threshold (worst 20% of subjects on any motion parameter excluded)	ADHD diagnosis	4664	−0.003	0.001	−3.25	0.001	-	−0.29 (−0.47 to −0.11)
Matched on covariates including QC variables	ADHD diagnosis	2087	−0.003	0.001	−2.49	0.01	-	−0.5 (−0.9 to −0.1)
Controlling for IQ	ADHD diagnosis	5814	−0.003	0.0009	−3.28	0.001		−0.26 (−0.41 to −0.1)
Excluding subjects with possible bipolar and/or psychosis symptoms	ADHD diagnosis	5506	−0.003	0.001	−3.42	0.0007	-	−0.28 (−0.43 to −0.12)

Abbreviations: ADHD, attention deficit hyperactivity disorder; CBCL, Child Behavior Checklist; IQ, intelligence quotient; QC, quality control.

^*p<.05

^**p<.01

^***p<.001.