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. Author manuscript; available in PMC: 2023 Mar 26.
Published in final edited form as: Thorax. 2022 Jan 21;77(7):707–716. doi: 10.1136/thoraxjnl-2021-217756

Figure 2. Predominance of Drive-Dependent Pathophysiology in OSA.

Figure 2.

Pooled data from all N=50 patients are shown. A) Histogram of individual events (N=4747) illustrates that drive typically falls rather than rises during events in OSA. B) Multi-patient ensemble-average traces exhibit ventilation and ventilatory drive synchrony; vertical dashed line illustrates the event start and solid vertical line illustrates event end. For illustrative purposes, multi-patient plots were generated by stretching/compressing individual patient ensemble averages (to align start and end times) before averaging (shading denotes 95%CI). Event duration was normalised to the group mean. C) During breaths within sleep, lowered drive is associated with a reduction in flow and genioglossus EMG, as well as an increased likelihood of respiratory events (color-bar).