Table 2.
Objective response rate (ORR) and ir(ORR) by histology and Programmed Death Ligand 1 (PD-L1) categories
| Best response N (%) (95% CI) |
Histologic type (N) | Total (N=35) N (%) |
||
| Papillary (19) | Chromophobe (6) | Unclassified (10) | ||
| CR | 1 (5.3)* | – | 1 (10) | 2 (5.7) |
| PR | – | 1 (16.7) | 2 (20)* | 3 (8.6) |
| SD | 11 (57.9) | 3 (50) | 2 (20) | 16 (45.7) |
| PD | 7 (36.8) | 2 (33.3) | 5 (50) | 14 (40) |
| ORR | 1 (5.3) | 1 (17) | 3 (30) |
5 (14.3) (4.8 to 30.3) |
| irORR | 1 (5.3) | 3 (50) | 4 (40) | 8 (22.9) (10.4 to 40.1) |
| PD-L1 >5% (N=11) | 1/3 | 1/4 | 1/4 | 3/11 (27.2) |
| PD-L1 <5% (N=18) | 0/13 | 0/2 | 0/3 | 0/18 (0) |
| PD-L1 NA (N=6) | 0/3 | – | 2/3 | 2/6 (33) |
*Sarcomatoid histology.
CR, complete response; irORR, immune-related ORR; NA, not available or missing; PD, progressive disease; PR, partial response; SD, stable disease.