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Target modulation in evaluable prostate tumors and bone marrow by daratumumab but not edicotinib as assessed by immunohistochemistry (IHC). (A) Quantitative CD38 IHC. (B) Representative H&E and CD38 IHC. (C) Quantitative CSF-1R IHC. (D) Representative H&E and CSF-1R IHC. Daratumumab-treated versus untreated prostate tumors and patient-matched pre-daratumumab and post-daratumumab bone marrow cores were assessed. CSF-1R, colony-stimulating factor-1 receptor; TME, tumor microenvironment.
