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. 2023 Mar 22;11(3):e005702. doi: 10.1136/jitc-2022-005702

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Swimmer plot of duration of treatment and tumor response over time per RECIST V.1.1 in patients with mCRPC. (A) Patients with mCRPC excluding Cohorts 7A-mCRPC and 3B-mCRPC. (B) Patients with mCRPC in Cohorts 7A-mCRPC and 3B-mCRPC. mITT population. Treatment of each cohort see the footnote of table 2. Measurable disease at baseline was defined as showing new or progressive metastatic lymph node and/or local recurrence or visceral metastatic disease (with the exception of metastases to the liver) on CT or MRI scans. Duration of treatment was defined as (last dose date−first dose date+1). One patient from Cohort 3B-mCRPC achieved a confirmed CR (CR was 1.5-cm para-aortic lymph node, patient withdrew from study therapy after early Grade 3 diarrhea). CR, complete response; mCRPC, metastatic castration-resistant prostate cancer; mITT, modified intention-to-treat; NE, not evaluated; PD, progressive disease; PR, partial response; RECIST, Response Evaluation Criteria in Solid Tumors; SD, stable disease.