Table 2.
DNAm sites with significant interaction between maternal methylation and newborn sex on neonatal methylation in the BBC and IOWBC
| DNAm site | Chr | BP | Mother–newborn pairs from the BBC | IOWBC – early-pregnancy pairs | IOWBC – pre-pregnancy pairs | Mapped gene | Functional annotation | Relation to CpG Island | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mother–newborn association | The interaction term of newborn sex and maternal DNAm level | Mother–newborn association P | The interaction term of newborn sex and maternal DNAm level | Mother–newborn association P | The interaction term of newborn sex and maternal DNAm level | ||||||||||||||
| P | FDR | Beta | s.e | P | FDR | Beta | s.e | P | Beta | s.e | P | ||||||||
| cg23532648 | X | 44,169,550 | 7.2 × 10–29 | 7.4 × 10–24 | 0.515 | 0.080 | 3.9 × 10–10 | 0.0003 | 0.001 | 0.704 | 0.655 | 0.30 | 0.002 | 0.459 | 0.282 | 0.11 | EFHC2 | Body | Island |
| cg26346636 | X | 41,301,703 | 6.1 × 10–7 | 1.8 × 10–5 | − 0.479 | 0.085 | 3.3 × 10–8 | 0.0104 | 0.01 | 0.195 | 0.491 | 0.70 | 0.0002 | − 0.068 | 0.200 | 0.74 | Island | ||
| cg10591659 | X | 41,306,768 | 1.5 × 10–18 | 1.2 × 10–15 | 0.454 | 0.082 | 5.3 × 10–8 | 0.0104 | 5.6 × 10–6 | − 1.210 | 0.431 | 0.02 | 0.001 | − 0.647 | 0.291 | 0.03 | NYX | 5'UTR/1stExon | |
| cg00478198 | X | 49,644,500 | 2.7 × 10–6 | 6.9 × 10–5 | − 0.283 | 0.051 | 5.8 × 10–8 | 0.0104 | 0.02 | − 0.283 | 0.333 | 0.41 | 0.99 | 0.009 | 0.221 | 0.97 | LOC158572 USP27X | TSS1500 5'UTR/1stExon | Island |
| cg06055266 | X | 53,111,187 | 4.4 × 10–8 | 1.8 × 10–6 | − 0.275 | 0.051 | 1.3 × 10–7 | 0.0135 | 0.32 | 0.258 | 0.321 | 0.44 | 0.004 | 0.278 | 0.140 | 0.05 | TSPYL2 | TSS1500 | N_Shore |
| cg00257859 | X | 9,815,644 | 4.1 × 10–28 | 2.4 × 10–23 | 0.404 | 0.075 | 1.3 × 10–7 | 0.0135 | SHROOM2 | Body | |||||||||
| cg00881203 | X | 149,930,926 | 1.4 × 10–14 | 2.9 × 10–12 | − 0.354 | 0.066 | 1.3 × 10–7 | 0.0135 | MTMR1 | Body | S_Shore | ||||||||
| cg01490258 | X | 40,030,456 | 1.8 × 10–6 | 4.7 × 10–5 | − 0.395 | 0.075 | 2.9 × 10–7 | 0.0260 | 0.14 | − 0.635 | 0.788 | 0.44 | 0.70 | − 0.037 | 0.173 | 0.83 | BCOR | 5'UTR | N_Shore |
| cg01911745 | 7 | 31,091,055 | 1.6 × 10–7 | 5.6 × 10–6 | − 0.396 | 0.076 | 3.6 × 10–7 | 0.0287 | ADCYAP1R1 | TSS1500 | N_Shore | ||||||||
| cg01483293 | 18 | 59,251,006 | 2.8 × 10–5 | 0.0005 | − 0.474 | 0.092 | 4.0 × 10–7 | 0.0289 | |||||||||||
| cg01963240 | 14 | 54,421,117 | 8.4 × 10–6 | 0.0002 | − 0.514 | 0.101 | 6.3 × 10–7 | 0.0413 | 3.2 × 10–14 | − 0.716 | 0.387 | 0.09 | 0.18 | 0.274 | 0.308 | 0.38 | BMP4 | 5'UTR | Island |
| cg25871420 | X | 23,348,969 | 9.5 × 10–15 | 2.1 × 10–12 | 0.380 | 0.076 | 8.3 × 10–7 | 0.0469 | 1.1 × 10–5 | 0.890 | 0.592 | 0.16 | 0.12 | 0.337 | 0.268 | 0.22 | N_Shore | ||
| cg02927373 | 19 | 51,347,703 | 5.9 × 10–5 | 0.001 | 0.476 | 0.095 | 8.4 × 10–7 | 0.0469 | LOC105372441 | Body | |||||||||
| cg06376279 | X | 19,585,128 | 1.3 × 10–19 | 1.5 × 10–16 | 0.423 | 0.085 | 9.5 × 10–7 | 0.0488 | SH3KBP1 | Body | |||||||||
| cg04149024 | X | 153,656,891 | 8.0 × 10–6 | 0.0002 | − 0.301 | 0.060 | 1.0 × 10–6 | 0.0493 | 0.11 | 0.438 | 0.445 | 0.35 | 0.57 | 0.029 | 0.173 | 0.87 | ATP6AP1 | TSS200 | Island |
Chr, chromosome; BP, position; FDR, false discovery rate; CpG, cytosine–phosphate–guanine dinucleotide; s.e., standard error