Table 2. Top 10 DMPs.
Details of the 10 most strongly associated sites identified with the LB algorithm. Position, Chromosome:bp (GRCh37); Nearest gene, nearest gene based on GRCh37 (Ensembl release 75); cis-eQTM, the top cis-eQTM for the respective probe; cis-eQTM FDR, P value corresponding to the top cis-eQTM, FDR-corrected for the number of tests for the respective probe; B, regression coefficient (representing the mean change in β values) and their 95% confidence intervals; P value, P value from the LB algorithm; PMS indicates that the probe is part of the respective PMS (polymethylation score); Trait, overlap with enriched traits from the MRC-IEU and NGDC EWAS databases (showing a maximum of five traits). HGF, hepatocyte growth factor; N.CDase, neutral ceramidase; FGF.21, fibroblast growth factor 21; CI, confidence interval.
| Probe | Position | Nearest gene | cis-eQTM (direction) | cis-eQTM FDR | B (95% CI) | P value | PMS | Traits |
|---|---|---|---|---|---|---|---|---|
| cg17901584 | 1:55353706 | DHCR24 | DHCR24 (−) | 2.9 × 10−62 | 0.0090 (0.0069–0.011) | 3.6 × 10−17 | BMI, HDL-c, and HGF | Hepatic fat, BMI, metabolic trait, and (serum) triglycerides |
| cg06528816 | 2: 47242277 | TTC7A | TTC7A (−) | 0.13 | 0.0035 (0.0026–0.0045) | 8.5 × 10−13 | Allergic sensitization and total serum IgE | |
| cg06500161 | 21: 43656587 | ABCG1 | ABCG1 (−) | 1.6 × 10−25 | −0.0052 (−0.0066 to −0.0038) | 1.2 × 10−12 | BMI, HDL-c, N.CDase, and FGF.21 | Hepatic fat, BMI, metabolic trait, and (serum) triglycerides |
| cg14945937 | 19: 30162771 | PLEKHF1 | PLEKHF1 (−) | 0.02 | −0.0041 (−0.0053 to −0.003) | 1.9 × 10−12 | ||
| cg08940169 | 16: 88540241 | ZFPM1 | PIEZO1* (−) | 0.08 | 0.0037 (0.0026–0.0048) | 7.8 × 10−12 | Allergic sensitization, total serum IgE, childhood asthma, and schizophrenia | |
| cg07571745 | 1:32715428 | FAM167B | CCDC28B* (−) | 0.26 | −0.0033 (−0.0042 to −0.0023) | 8.9 × 10−12 | ||
| cg14195992 | 8: 48265917 | SPIDR | SPIDR (−) | 0.0059 | −0.0053 (−0.0068 to −0.0037) | 4.8 × 10−11 | Birth weight | |
| cg08851837 | 16: 57558820 | CCDC102A | GPR56* (+) | 0.84 | 0.0045 (0.0032–0.0059) | 5.8 × 10−11 | ||
| cg09257526 | 1:154379696 | IL6R | ATP8B2* (−) | 0.0031 | −0.0023 (−0.003 to −0.0016) | 5.9 × 10−11 | Alcohol consumption per day | |
| cg15782984 | 6: 35993792 | SLC26A8 | SLC26A8 (−) | 0.007 | −0.0046 (−0.0059 to −0.0032) | 9.5 × 10−11 |
The association between DNA methylation and the nearest gene was not significant (FDR > 0.05)