Table 3. Gene set enrichments.

Details of the gene sets that were significantly enriched (FDR < 0.05) among the MOA and LB results based on nearest genes annotated to each site. Method, EWAS method and P value cutoff applied to the respective EWAS test statistics resulting in the input probes for the shown enrichment analyses; N overlap, number of genes that overlap with genes in the respective pathway; N genes, total number of genes in the pathway; FDR, FDR-controlled P values (Wallenius’ noncentral hypergeometric distribution).

Method	Database	Pathway	N overlap	N genes	FDR
LB (P < 0.001)	KEGG	Cytokine-cytokine receptor interaction	36	262	0.0012
	KEGG	NK cell-mediated cytotoxicity	22	108	0.036
MOA (P < 0.001)	–	–	–	–	–
LB (P < 9 × 10−8)	–	–	–	–	–
MOA (P < 9 × 10−8)	KEGG	Steroid biosynthesis	2	18	0.015
	GO BP	Cholesterol biosynthetic process	3	71	0.021
	GO BP	Sterol biosynthetic process	3	77	0.021
	GO BP	Organic hydroxy compound biosynthetic process	4	251	0.021
	GO BP	Secondary alcohol biosynthetic process	3	71	0.021