Table 2. Coefficients of correlation between pharmacokinetic parameters of lidocaine (LID) and Child-Pugh score.
*significant correlation at the 0.05 level<br>**significant correlation at the 0.001 level
Lidocaine (LID)<br>pharmacokinetic <br>parameters | Coefficient of correlation<br>with Child-Pugh score | ||
---|---|---|---|
all<br>patients | patients<br>with cirrhosis | patients<br>with tumor | |
clearance (CL) | - 0.434* | - 0.693** | - 0.543** |
distribution (Vd) | - 0.101 | - 0.250 | - 0.132 |
half-life (t1/2) | 0.350* | 0.346 | 0.465** |