Comparison 4. NSAIDs versus placebo, adverse effects.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Overall side effects (random‐effects model)	2	220	Risk Ratio (M‐H, Random, 95% CI)	2.94 [0.51, 17.03]
2 GI complaint (fixed‐effect model)	3	189	Risk Ratio (M‐H, Fixed, 95% CI)	0.76 [0.17, 3.32]
3 Lethargy/drowsiness (fixed‐effect model)	2	110	Risk Ratio (M‐H, Fixed, 95% CI)	1.0 [0.14, 6.91]
4 Feeling hyperactive	1	46	Risk Ratio (M‐H, Fixed, 95% CI)	3.0 [0.13, 70.02]
5 Feeling more awake	1	46	Risk Ratio (M‐H, Fixed, 95% CI)	3.0 [0.13, 70.02]
6 Flushed face	1	46	Risk Ratio (M‐H, Fixed, 95% CI)	3.0 [0.13, 70.02]
7 Difficulty sleeping	1	46	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.01, 7.78]
8 Light‐headedness	1	46	Risk Ratio (M‐H, Fixed, 95% CI)	1.0 [0.15, 6.51]
9 Dry mouth	1	46	Risk Ratio (M‐H, Fixed, 95% CI)	3.0 [0.13, 70.02]