Graham 1990.

Methods	Double‐blind, placebo‐controlled, experimental colds
Participants	59 inoculated; 42 colds. Mean age 20.1 years, 43.3% women, university students
Interventions	2 groups: aspirin 4 g/day and ibuprofen 1.2 g/day for 7 days
Outcomes	The proportion of nasal obstruction score > 5 in the aspirin group (6/15) significantly differed from that in the placebo group (0/14, P value < 0.05) Mean mucus weight, mean tissue count, mean overall symptom score and mean overall side effect score were reported but any other statistical parameters such as SD, SE, 95% CI and P value for each group or the difference between these groups were not reported
Notes	—
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"... a randomised double‐blind, placebo‐controlled clinical trial"
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding (performance bias and detection bias) All outcomes	Low risk	"... identical capsules containing aspirin (500 mg), ibuprofen (200 mg) or placebo" Comment: probably done
Incomplete outcome data (attrition bias) All outcomes	Low risk	"... 4 volunteers who were considered uninfected and were excluded from further analyses" Comment: probably done
Selective reporting (reporting bias)	Unclear risk	No protocol, no convincing text
Other bias	Low risk	The study appears to be free of other sources of bias