Ryan 1987.

Methods	Double‐blind, placebo‐controlled, natural colds
Participants	64 adults, age range 18 to 60 years, 75% women, single family centre, fever ≤ 37.8 °C with moderate pain due to malaise/aches
Interventions	Fenoprofen 200 mg single dose
Outcomes	No available data on efficacy
Notes	Only 2 adverse effects (1 stomach discomfort and 1 drowsiness), both in the fenoprofen group
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"... assigned to one of three treatment groups via a computer‐generated random table"
Allocation concealment (selection bias)	Low risk	"Each dose of medication was dispensed in identically appearing capsules" Single oral dose was given Comment: probably done
Blinding (performance bias and detection bias) All outcomes	Low risk	"Each dose of medication was dispensed in identically appearing capsules in double‐blind method" Single oral dose was given Comment: probably done
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants who entered the study completed treatment and were included in the assessment of effectiveness and side effects
Selective reporting (reporting bias)	Unclear risk	No protocol, no convincing text
Other bias	Low risk	The study appears to be free of other sources of bias