Table 2:

Kynurenine Metabolites by IBU Dosage. Mean (SEM) and Cohen’s D of each metabolite and ratio grouped by IBU dose condition. Unadjusted Cohen’s D statistics are given for the difference between the IBU dose condition and placebo (reference). Units in ratios converted to nM where necessary.

IBU Dose	Placebo	200mg		600mg
	Mean(SEM)	Mean(SEM)	Cohen’s D	Mean(SEM)	Cohen’s D
TRP (μM)	51.5 (2.1)	46.0 (1.8)	0.64	44.0 (1.9)	0.86
KYN (μM)	1.64 (0.07)	1.58 (0.06)	0.22	1.60 (0.07)	0.13
KynA (nM)	30.4 (2.5)	31.3 (2.0)	0.09	37.0 (2.7)	0.57
3HK (nM)	22.8 (1.9)	22.3 (0.9)	0.06	24.2 (1.3)	0.19
QA (nM)	262 (18)	261 (14)	<0.01	264 (15)	0.03
KYN/TRP	0.032 (0.001)	0.035 (0.02)	0.39	0.07 (0.002)	0.63
KynA/KYN	0.019 (0.001)	0.020 (0.002)	0.28	0.024 (0.002)	0.71
KynA/3HK	1.43 (0.11)	1.45 (0.12)	0.04	1.57 (0.12)	0.29
KynA/QA	0.12 (0.01)	0.13 (0.01)	0.04	0.15 (0.02)	0.45

IBU = ibuprofen, TRP = tryptophan, KYN = kynurenine, KynA = kynurenic acid, 3HK = 3-hydroxykynurenine, QA = quinolinic acid, SEM = standard error of the mean