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. 2023 Mar 7;16(3):dmm049750. doi: 10.1242/dmm.049750

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© 2023. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Peritumoral HSC activation in early-stage mouse and patient liver tumors. (A) Images of αSMA IHC and matching ZsG/DAPI fluorescence of 3-week PPTR liver tumors generated via tail vein injection. Arrows indicate αSMA⁺ cells at the tumor border. T, tumor. Scale bar: 100 µm. Images are representative of tumors from five mice. (B) H&E staining and αSMA IHC of two intrahepatic cholangiocarcinoma (iCCA) and one hepatocellular carcinoma (HCC) early-stage tumors from patients. Arrows indicate αSMA⁺ cells at the tumor border. Scale bars: 100 µm.