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. Author manuscript; available in PMC: 2023 Mar 26.
Published in final edited form as: Lancet Diabetes Endocrinol. 2022 Jul 5;10(8):589–596. doi: 10.1016/S2213-8587(22)00141-3

Figure 2: Bootstrap replication for optimal screening ages.

Figure 2:

(A) Analyses of optimal ages for screening of any islet autoantibodies for risk of type 1 diabetes by age 15 years in the T1DI cohort using bootstrap internal replication for each age pair. The four testing-age combinations with the greatest comparative sensitivities are shown. Testing at ages 2 years and 6 years performed best (smallest distance to the upper-left corner of the plot). (B) Using the testing age pair of 2 years and 6 years from panel A as a reference, we compared all other age combinations using internal bootstrapping replication. For each age combination, the dark area of the pie chart represents the proportion of screening tests resulting in a distance to the top-left corner in panel A at or below that of the age 2-year and 6-year test pair. No other combination was superior to testing at age 2 years and 6 years. T1DI=Type 1 Diabetes Intelligence.