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. Author manuscript; available in PMC: 2023 Mar 26.
Published in final edited form as: Lancet Diabetes Endocrinol. 2022 Jul 5;10(8):589–596. doi: 10.1016/S2213-8587(22)00141-3

Figure 3: Comparison of performance metrics by HLA background and study cohort.

Figure 3:

(A) Comparative sensitivity (green) and PPV (purple) with 95% CIs of any islet antibodies at ages 2 years and 6 years for high-risk combined HLA groups A plus B versus lower-risk combined HLA groups C plus D. (B) Comparative sensitivity with 95% CIs of any islet autoantibodies with a two-age strategy using different age pairs and different study populations. Maximum sensitivity was at age pair 2 years and 6 years (blue) for DIPP (Finland), but age 2 years and 9 years (red) for DAISY (Colorado, USA). PPV=positive predictive value. DIPP=Diabetes Prediction and Prevention. DAISY=Diabetes Autoimmunity Study in the Young.