TABLE 1.
Patient characteristics
| Characteristics | Overall N = 63 | ECOG‐PS 2 N = 38 | ECOG‐PS ≥3 N = 25 | p value |
|---|---|---|---|---|
| Age at diagnosis, median, years (range) | 76 years (71–86) | 76 years (71–86) | 75 years (71–84) | 0.578 |
| 71–74 years | 22 (34.9) | 12 (31.6) | 10 (40.0) | |
| 75–79 years | 24 (38.1) | 14 (36.8) | 10 (40.0) | |
| ≥80 years | 17 (27.0) | 12 (31.6) | 5 (20.0) | |
| Gender, n (%) | 0.592 | |||
| Male | 50 (79.4) | 31 (81.6) | 19 (76.0) | |
| Female | 13 (20.6) | 7 (18.4) | 6 (24.0) | |
| ECOG‐PS, n (%) | ||||
| 2 | 38 (60.3) | 38 | 0 | |
| 3 | 24 (38.1) | 0 | 24 | |
| 4 | 1 (1.6) | 0 | 1 | |
| Smoking status, n (%) | 0.773 | |||
| Current | 35 (55.6) | 20 (52.6) | 15 (60.0) | |
| Former | 26 (41.3) | 17 (44.7) | 9 (36.0) | |
| Never | 2 (3.2) | 1 (2.6) | 1 (4.0) | |
| Clinical stage (UICC‐TNM 8th), n (%) | 0.605 | |||
| III | 5 (7.9) | 4 (10.5) | 1 (4.0) | |
| IVA | 25 (39.7) | 14 (36.8) | 11 (44.0) | |
| IVB | 33 (52.4) | 20 (52.6) | 13 (52.0) | |
| Metastases at baseline, n (%) | ||||
| Brain | 18 (28.6) | 11 (28.9) | 7 (28.0) | 0.935 |
| Lung | 20 (31.7) | 14 (36.8) | 6 (24.0) | 0.284 |
| Liver | 18 (28.6) | 10 (26.3) | 8 (32.0) | 0.625 |
| Adrenal | 16 (25.4) | 8 (21.1) | 8 (32.0) | 0.329 |
| Bone | 19 (30.2) | 12 (31.6) | 7 (28.0) | 0.762 |
| Malignant pleural effusion | 18 (28.6) | 8 (21.1) | 10 (40.0) | 0.103 |
| Radiation therapy for baseline BM before systemic chemotherapy, n (%) | 9 (14.3) | 4 (10.5) | 5 (20.0) |
Abbreviations: ECOG‐PS, Eastern Cooperative Oncology Groups Performance Status; UICC‐TNM 8th, Union International for Cancer Control‐TNM 8th edition.