Table 2.
Frequency of COVID-19 signs and symptoms at the disease onset in the sample as a whole and by a history of hypothyroidism
| All (n = 1245) | History of hypothyroidism | p value | ||
|---|---|---|---|---|
| No (n = 1112) | Yes (n = 75) | |||
| Symptoms/signs of COVID-19 | ||||
| Fever | 708 (56.9) | 633 (56.9) | 75 (56.8) | 0.317 |
| Pharyngodynia | 48 (3.9) | 42 (3.8) | 6 (4.5) | 0.152 |
| Cough | 443 (35.6) | 395 (35.5) | 48 (36.4) | 0.456 |
| Sneezing | 52 (4.2) | 46 (4.1) | 6 (4.5) | 0.117 |
| Dyspnoea* | 610 (49.0) | 550 (49.4) | 60 (45.5) | 0.200 |
| Low oxygen saturation* | 607 (48.8) | 551 (49.5) | 56 (42.4) | 0.031 |
| Tachypnea* | 420 (33.7) | 378 (34.0) | 42 (31.8) | 0.08 |
| Weakness | 479 (38.5) | 436 (39.2) | 43 (32.6) | 0.07 |
| Fall or fainted | 45 (3.6) | 37 (3.3) | 8 (6.1) | 0.109 |
| Muscle aching | 60 (4.8) | 48 (4.3) | 12 (9.1) | 0.02 |
| Delirium | 86 (6.9) | 78 (7.0) | 8 (6.1) | 0.342 |
| Loss of smell | 11 (0.9) | 8 (0.7) | 3 (2.3) | 0.013 |
| Loss of taste | 14 (1.1) | 10 (0.9) | 4 (3.0) | 0.06 |
| Anorexia | 123 (9.9) | 117 (10.5) | 6 (4.5) | 0.01 |
| Gastrointestinal symptoms | 134 (10.8) | 123 (11.1) | 11 (8.3) | 0.164 |
| Sudden health worsening | 240 (19.3) | 213 (19.1) | 27 (20.5) | 0.221 |
| Inflammatory markers | ||||
| WBC [× 109/l] | 7.6 (6.0) | 7.7 (6.2) | 6.9 (4.2) | 0.28 |
| Neutrophils [%] | 74.2 (14.9) | 74.5 (15.2) | 71.7 (12.7) | 0.15 |
| Lymphocytes [%] | 15.7 (10.2) | 15.3 (10.0) | 19.5 (11.1) | 0.001 |
| NLratio | 8.4 (11.6) | 8.7 (12.1) | 6.0 (5.9) | 0.078 |
| LDH [U/l] | 362.1 (204.7) | 366.8 (211.0) | 322.9 (136.9) | 0.126 |
| CRP [mg/l] | 108.6 (344.7) | 112.1 (361.0) | 76.7 (122.1) | 0.426 |
| Procalcitonin [ng/ml] | 1.4 (7.0) | 1.4 (7.3) | 1.1 (3.8) | 0.801 |
| Disease severity (WHO) | 0.164 | |||
| No oxygen therapy | 313 (25.1) | 276 (24.8) | 37 (28.0) | 0.482 |
| Low-flow oxygen therapy | 476 (38.2) | 422 (37.9) | 54 (40.9) | 0.566 |
| High-flow oxygen therapy, NIV or intubation | 295 (23.7) | 274 (24.6) | 21 (15.9) | 0.034 |
Missing in fever n = 314, pharyngodynia n = 434, cough n = 376, sneezing n = 431, dyspnea n = 336, low SpO2 n = 371, tachypnea n = 437, weakness n = 437, fall or fainted n = 486, muscle aching n = 507, delirium n = 460, loss of smell n = 590, loss of taste n = 591, anorexia n = 497, gastrointestinal symptoms n = 462, sudden health worsening n = 462, WBC n = 823, neutrophils n = 507, lymphocytes n = 628, NLratio n = 620, CRP n = 725, procalcitonin n = 587, oxygen requirements n = 161
CRP C-reactive protein, LDH lactic dehydrogenase, NLratio neutrophil-to-lymphocyte ratio, WBC white blood cell count
p values < 0.05 are shown in bold
*Data are in ambient air