Table 2.
Significantly differentially expressed proteins
| Gene names | Protein names | ANOVA | q-value | Mean difference | Andromeda score | |
|---|---|---|---|---|---|---|
| COV-POS | COV-NEG | HCO | ||||
| IGHG1 | Ig gamma-1 chain C region | 0.004 | 4.4 | -3.0 | -4.4 | 323 |
| IGKC | Ig kappa chain C region | 0.011 | 3.1 | -3.1 | 2.2 | 323 |
| ORM1 | Alpha-1-acid glycoprotein 1 | 0.012 | 2.8 | − 2.8 | − 2.6 | 165 |
| SFTPB | Pulmonary surfactant-associated protein B | 0.016 | − 2.7 | − 2.2 | 2.7 | 69 |
| TF | Serotransferrin | 0.021 | 2.9 | − 2.9 | 0.0 | 323 |
| IGHA1 | Ig alpha-1 chain C region | 0.022 | 1.3 | − 2.9 | 2.9 | 323 |
| CASP14 | Caspase-14 | 0.027 | − 2.6 | 2.6 | 1.5 | 323 |
| EPPK1 | Epiplakin | 0.029 | 2.6 | − 1.4 | − 2.6 | 292 |
| CAPN1 | Calpain-1 catalytic subunit | 0.033 | − 2.3 | 2.3 | 1.4 | 61 |
| IGLC6 | Ig lambda-6 chain C region | 0.034 | 2.5 | − 2.5 | 1.4 | 229 |
| APOA1 | Apolipoprotein A-I | 0.036 | 2.4 | − 2.4 | 0.0 | 308 |
| CAT | Catalase | 0.036 | − 1.4 | 2.2 | − 2.2 | 323 |
| DSC3 | Desmocollin-3 | 0.037 | − 2.2 | 2.2 | − 1.7 | 270 |
| VCL | Vinculin | 0.040 | − 1.8 | − 1.8 | 1.8 | 52 |
| PKP1 | Plakophilin-1 | 0.041 | − 2.1 | 2.1 | 0.0 | 323 |
| TGM1 | Protein-glutamine gamma-glutamyltransferase K | 0.043 | − 1.8 | 1.8 | − 1.5 | 261 |
| PSMA3 | Proteasome subunit alpha type-3 | 0.043 | − 2.1 | 2.1 | 1.7 | 88 |
| ZG16B | Zymogen granule protein 16 homolog B | 0.043 | 0.0 | − 2.2 | 2.2 | 323 |
| ARG1 | Arginase-1 | 0.044 | − 2.1 | 2.1 | 0.0 | 323 |
| SERPINA1 | Alpha-1-antitrypsin | 0.044 | 2.2 | − 2.2 | 0.0 | 323 |
| ACTN4 | Alpha-actinin-4 | 0.046 | 2.0 | − 1.3 | − 2.0 | 65 |
| S100A14 | Protein S100-A14 | 0.047 | − 1.9 | 1.9 | 0.0 | 227 |
| TXN | Thioredoxin | 0.048 | − 1.3 | − 1.8 | 1.8 | 84 |
| PIGR | Polymeric immunoglobulin receptor | 0.048 | − 1.6 | − 1.6 | 1.6 | 109 |
| HP | Haptoglobin | 0.049 | 2.0 | 0.0 | − 2.0 | 188 |
| PLBD1 | Phospholipase B-like 1 | 0.049 | − 1.9 | 1.9 | 0.0 | 76 |
Summary of significantly differentially expressed proteins between PCR-verified COVID-19 infection (COV-POS), COVID-19 PCR-negative patients with respiratory symptoms (COV-NEG) and healthy controls (HCO) and their adjusted p-value (ANOVA q-value) and Andromeda score from the MaxQuant search engine