Table 2.
Meta-analysis and certainty of evidence for controlled studies involving COVID-19 vaccines in pregnant persons.
| Outcome | Trimester Ex. | aOR (95% CI) | # Studies (Ex vs. no-Ex) | I2 | GRADE |
|---|---|---|---|---|---|
| Abortion, spontaneous or inducedmOR[40] | All | 1.09 (0.84, 1.40) | 1 (7530 vs 7530) | NA | Very low1 |
| StillbirthmOR[40] | All | 0.50 (0.05, 5.51) | 1 (7530 vs 7530) | NA | Very low1 |
| Congenital malformations[87] | 2nd/3rd | 0.89 (0.24 to 3.31) | 1 (133 vs 399) | NA | Very low1 |
| Preterm birthmOR[40] | All | 0.90 (0.66, 1.23) | 1 (7530 vs 7530) | NA | Very low1 |
| Small for gestational age[87] | 2nd/3rd | 1.00 (0.55 to 1.82) | 1 (133 vs 399) | NA | Very low1 |
| Fetal growth restrictionmOR[40] | All | 0.95 (0.60, 1.50) | 1 (7530 vs 7530) | NA | Very low1 |
| Pre-eclampsiamOR[40] | All | 0.95 (0.52, 1.76) | 1 (7530 vs 7530) | NA | Very low1 |
| Postpartum hemorrhage[87] | 2nd/3rd | 1.09 (0.56 to 2.12) | 1 (133 vs 399) | NA | Very low1 |
aOR: adjusted Odds Ratio; mOR: OR calculated from the matched study population by age, gestational age, residential area, population subgroup, number of prior children, and having a seasonal influenza vaccine (Goldshtein 2021).
in the last year; CI: Confidence interval; NA; Not applicable; Ex: Exposure; 1st: first; 2nd: second; 3rd: third.
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1.GRADE certainty of evidence: started “Low” due to the observational designs, and was downgraded two levels due to very serious imprecision (crossing the null effect, and 95%CI < 0.5 and/or > 1.50.