REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rat-anti-IGFBP2	R&D systems	Cat# MAB7971; RRID:AB_2264598
Rabbit anti-IGFBP2 for IHC	Abcam	Cat# ab188200
Rabbit anti-P21	Abcam	Cat# ab188224; RRID:AB_2734729
Rabbit anti-Collagen 1	EMD Millipore	Cat# AB765P; RRID:AB_92259
Rabbit anti-PPARα	LSBio	Cat# LS-C312574
Rabbit anti-Fibronectin	Abcam	Cat# ab2413; RRID:AB_2262874
Rabbit anti-Vimentin	CST	Cat# 5741S; RRID:AB_10695459
HRP conjugated-β actin	Santa Cruz	Cat# sc-47778HRP; RRID:AB_2714189
Mouse anti-α tubulin	CST	Cat# 3873; RRID:AB_1904178
Rabbit anti-H3 Histone	CST	Cat# 4499; RRID:AB_10544537
Rabbit anti-phospho-Histone 2AX	CST	Cat# 2577; RRID:AB_2118010
Rabbit anti-Prosurfactant Protein C	Abcam	Cat# ab211326; RRID:AB_2927746
Bacterial and virus strains
Ad-Null	Vector Biolabs	Cat#1240
Ad-m-TGFβ1	Vector Biolabs	Cat#ADV-274099
mouse Igfbp2 lentiviral particle	Origene	Cat#: MR204287L3V
Lenticontrol particles	Origene	Cat# PS100092V
Chemicals, peptides, and recombinant proteins
human IGFBP2 recombinant protein	R&D Systems	Cat# 797-B2-025
Bleomycin	EMD Millipore	Cat# 203401
DMSO	Sigma- Aldrich	Cat# D8418
4% PFA	Santa Cruz	Cat# sc-281692
DMEM/F12	Gibco	Cat# 11-320-033
Plasmocin	invivogen	Cat# ant-mpp
Collagenase type 1	Worthington Biochemical	Cat# LS004197
Dispase	Corning	Cat# 354235
Green chromogen	Leica	Cat# DC9913
Bond polymer refine system	Leica	Cat# DS9800
BondTM Primary antibody diluent	Leica	Cat# AR9352
BOND Epitope Retrieval Solution 1	Leica	Cat# AR9961
BOND Epitope Retrieval Solution 2	Leica	Cat# AR9640
Wash solution 10X concentration	Leica	Cat# AR9590
BOND Universal Covertile	Leica	Cat# S21.4611
Tween-20	Sigma- Aldrich	Cat# P9416
PVDF membrane	EMD Millipore	Cat# IPVH00010
SuperSignalTM Pico or Femto substrate	Thermo Fisher Scientific	Cat# 34095
RIPA buffer	Thermo Fisher scientific	Cat# 89901
Igfbp2	Life science technology	Hs01040719_m1
18S rRNA	Life science technology	Hs99999901_s1
Pparα	Life science technology	Mm00440939_m1 and Hs00231882_m1
Igfbp2 siRNA	Horizon Discovery	L-062198-01-0005
Pparα siRNA	Santa Cruz	sc-36308
Critical commercial assays
High-Capacity RNA-to-cDNA™ Kit	Thermo Fisher scientific	Cat# 4387406
TaqMan™ Fast Advanced Master Mix	Thermo Fisher scientific	Cat# 44-445-56
Hydroxyproline assay	Cell Biolab	Cat# STA-675
Βeta-galactosidase activity assay	Biovision	Cat# K821- 100
RT2 profiler PCR assay	Qiagen	Cat# PAMM-050ZC-6
IGFBP2 ELSA assay	R&D systems	Cat# DY797
BCA protein assay	Thermo Fisher Scientific	Cat# 23227
Experimental models: Cell lines
MLE-12	ATCC	CRL-2110
Experimental models: Organisms/strains
Igfbp2flx/flxtransgenic mouse	Leeds University
Sftpc-CreERT2	The Jackson Laboratory	RRID#IMSR_JAX:028054
C57BL6/J	The Jackson Laboratory	RRID#IMSR_JAX:000664
Oligonucleotides
IL-1βCCH	PrimerBank ID 6680415a1	5′-GCAACTGTTCCTGAACTCAACT-3′ and 5′-ATCTTTTGGGGTCCGTCAACT-3′
IL-4	PrimerBank ID 10946584a1	5′- GGTCTCAACCCCCAGCTAGT-3′ 5′- GCCGATGATCTCTCTCAAGTGAT-3′
IL-6	PrimerBank ID 13624311a1	5′-TAGTCCTTCC-3′ 5′-TACCCCAATTTCC-3′
MCP-1	PrimerBank ID 6755430a1	5′- TTAAAAACCTGGATCGGAACCAA-3′ 5′- GCATTAGCTTCAGATTTACGGGT-3′
STAT-3	PrimerBank ID 13277852a1	5′- CAATACCATTGACCTGCCGAT-3′ 5′- GAGCGACTCAAACTGCCCT-3′
STAT6	PrimerBank ID 6678155a1	5′- CTCTGTGGGGCCTAATTTCCA-3′ 5′- CATCTGAACCGACCAGGAACT-3′
TNF-α	PrimerBank ID 7305585a1	5′- CCCTCACACTCAGATCATCTTCT-3′ 5′- GCTACGACGTGGGCTACAG-3′
Software and algorithms
ImageJ 1.53t	FIJI	https://imagej.nih.gov/ij/
Graphpad Prism 9.0	Graphpad software LLC	https://www.graphpad.com