Figure 2.

FCGR-binding titers are correlates of the development of neutralization breadth

(A–E) UpSet chart (A) shows number of individuals who seroconvert to a given vaccine strain or strains (n = 108). Vertical bars show seroconversion groups across all possible combinations of four vaccine strains. Horizontal bars show total individuals seroconverting to each strain, regardless of other strains seroconverted. Dot plot (B) shows correlation between percentage of strains seroconverted and breadth score across all strains included in Table S1. Dot plot (C) represents PLSR for delta values regressed against breadth in the test cohort. Loadings plot (D) represents relative contributions of LASSO-elastic net selected features for the model, with features plotted to represent where they have highest values if overlaid on the PLSR plot. Dot plots (E) show significantly different LASSO-elastic net selected features as univariate plots binned by quartile of breadth score. Significance (E) was tested by Kruskal-Wallis test followed by Dunn’s multiple comparisons correction. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001. This figure shows data from the Discovery cohort.

See also Figure S2.