Figure 4.

FCGR2B-binding antibodies are a predictor of neutralizing breadth

(A–D) Dot plot (A) represents PLSR for day 0 values regressed against breadth score in the Investigation cohort (n = 387). Loadings plot (B) represents relative contributions of LASSO-elastic net selected features for each model. Dot plots (C) represent univariate values for the LASSO-elastic net selected features, with individual samples binned by quartile of breadth score. Significance was tested by Kruskal-Wallis test followed by Dunn’s multiple comparisons correction. ∗p < 0.05. Networks (D) show significant (R > 0.6 and false discovery rate-corrected Q < 0.01) co-correlates of LASSO-elastic net selected features as shown in (B), where stronger red edges indicate stronger correlations and node shape and color reflects strain and measurement type. All antigens are HA unless otherwise noted. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗∗p < 0.0001.

See also Figure S4.