Table 1.
Summary of Differentially Expressed Genes at 6 Weeks and 12 Months Post-Blast Exposure
| Time post-blast | Area | Total DEGs | DEGs up | DEGs down |
|---|---|---|---|---|
| 6 weeks | Amygdala | 8 | Col5a1, C3, Rpl21, Fance | Gad2, Tac1, Nxph, Ahi1 |
| 6 weeks | Anterior cortex | 3 | Tsc22d4 | Fundc2, AC134224.3 |
| 6 weeks | Hippocampus | 0 | 0 | 0 |
| 6 weeks | Cerebellum | 22 | Wdr66, Ak5, LOC100365697, AABR07053509.2, Chd7, Camk1g, Gria2, Plekha5, Cemip, Pigk, Zfhx2, Kcnb1, Crebbp, Myt1, Per3 | Cam2k, Fundc2, Col9a2, Mras, Rpl12, Comtdi, Prdx2. |
| 12 months | Amygdala | 17 | Hapln4, ATP6v0c |
AABR07015057.1, AABR07063425.2 Mast2, Agpat3, AABR07015079, Chd3, Abcd3, Ttbk1, Mobp, Tmem151b, Cbx6, Csnk1g2 AABR07015081.1, AABR07015081.2, AC134224.1 |
| 12 months | Anterior cortex | 0 | 0 | 0 |
| 12 months | Hippocampus | 1 | 0 | Map3k7 |
| 12 months | Cerebellum | 2 | Aurkb, Mmp14 | 0 |
DEGs, differentially expressed genes; Col5a1, collagen alpha-1(V); Rpl21, ribosomal protein L2; Fance, FA complementation group E; Tsc22d4, TSC22 domain family member 4; Wdr66, WD repeat-containing protein 66; Ak5, adenylate kinase 5; Chd7, chromodomain-helicase-DNA-binding protein 7; Camk1g, calcium/calmodulin dependent protein kinase IG; Gria2, glutamate ionotropic receptor AMPA type subunit 2; Plekha5, pleckstrin homology domain containing A5; Cemip, cell migration inducing hyaluronidase 1; Pigk, phosphatidylinositol glycan anchor biosynthesis class K; Zfhx2, zinc finger homeobox 2; Kcnb1, potassium voltage gated channel subfamily b member 1; Crebbp, cyclic adenosine monophosphate response element binding protein; Myt1, myelin transcription factor 1; Per3, period circadian regulator 3; Hapln4, hyaluronan and proteoglycan link protein 4; ATP6v0c, ATPase H+ transporting V0 subunit C; Aurkb, aurora kinase B; Mmp14, matrix metallopeptidase 14; Gad2, glutamate decarboxylase 2; Tac1, tachykinin precursor 1; Nxph, neurexophilin 1; Ahi1, abelson helper integration site 1; Fundc2, FUN14 domain containing 2; Cam2k, calcium/calmodulin-dependent protein kinase type II; Col9a2, collagen type IX alpha 2 chain; Mras, muscle RAS oncogene homolog; Rpl12, ribosomal protein L12; Comtd1, catechol-o-methyltransferase domain containing 1; Prdx2; peroxiredoxin 2; Mast2, microtubule associated serine/threonine kinase 2; Agpat3, 1-acylglycerol-3-phosphate o-acyltransferase 3; Chd3, chromodomain-helicase-DNA-binding protein 3; Abcd3, ATP binding cassette subfamily D member 3; Ttbk1, tau tubulin kinase 1; Mobp, myelin associated oligodendrocyte basic protein; Tmem151b, transmembrane protein 151B; Cbx6, chromobox 6; Csnk1g2, casein kinase 1 gamma 2; Map3k7, mitogen-activated protein kinase kinase kinase 7.