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. Author manuscript; available in PMC: 2023 Mar 27.
Published in final edited form as: Nat Biomed Eng. 2023 Feb 6;7(3):270–280. doi: 10.1038/s41551-023-01003-7

Extended Data Fig. 5 |. In vivo biodistribution study of ICG, ZW800–1A, and ZW800–1C in CD-1 mice.

Extended Data Fig. 5 |

25 nmol of ZW800–1C was injected in 25 g CD-1 mice 4 h prior to imaging. (a) Representative color and NIR images of ZW800–1C showing major organs in the thoracic cavity (left), abdominal cavity (middle), and after resection (right). (b) Signal-to-background ratio (SBR) of resected major organs (Or) against muscle (Mu). Abbreviations used are He, heart; Lu, lung; Li, liver; Pa, pancreas; Sp, spleen; Ki, kidney; Du, duodenum; Ga, gallbladder; BD, bile duct; Bl, bladder; In, intestine. ***P = 0.0006 and ****P < 0.0001 by two-way ANOVA with Dunnett’s multiple comparison test. (c) Comparison of the pharmacokinetic parameters of the candidate NIR fluorophores. Abbreviations used are t1/2α, distribution blood half-life; t1/2β, elimination blood half-life; Vd, the volume of distribution; AUC, area under the curve; Cl, clearance. Data are shown as mean ± s.e.m.