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. 2023 Mar 21;4(3):100979. doi: 10.1016/j.xcrm.2023.100979

Figure 1.

Figure 1

Mice have significant differences in susceptibility to intestinal I/R-induced enterogenic sepsis

(A) Schematic diagram of differences in susceptibility to enterogenic sepsis in mice.

(B) Mouse survival curve (n = 20; chi-square test).

(C and D) Hematoxylin and eosin (HE) staining (C) and the pathological damage scores (D) of intestinal tissue sections. Scale bar, 100 μm (n = 8).

(E–G) The fluorescein isothiocyanate (FITC)-dextran levels (E) and 16S/18S levels in blood cells (F) and endotoxin levels in plasma (G) reflect the permeability of the intestinal barrier and bacterial translocation (n = 8).

(H–J) Mouse lung tissue HE staining (H); the pathological damage scores (I) and wet/dry weight ratios (J). Scale bar, 100 μm (n = 8).

(K–N) Mouse liver tissue HE staining (K); the pathological damage scores (L) and plasma ALT (M) and AST levels (N). Scale bar, 100 μm (n = 8).

(O–Q) Mouse kidney tissue HE staining (O); the pathological damage scores (P) and plasma BUN levels (Q). Scale bar, 100 μm (n = 8). The results are expressed as the median and quartile. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 by were determined by the Mann-Whitney test.