Table 1:
Statistics of the MCI population.
| Feature | MCI (N=325) |
|---|---|
| Female (%) | 44.9 |
| Age (years, mean±SD) | 71.08 ± 7.30 |
| Education in years (years, mean±SD) | 16.18 ± 2.68 |
| Family History (%) | 65.23 |
| APOE ɛ4 (% of >=1 allele) | 47.38 |
| The MRI volumetric features (volumes in mm3, mean±SD) | |
| Ventricles | 0.024 ± 0.012 |
| Hippocampus | 0.005 ± 8e-04 |
| Middle temporal gyrus | 0.013 ± 0.0016 |
| Entorhinal | 0.002 ± 4e-04 |
| Fusiform | 0.012 ± 0.0014 |
| Cognitive tests (scores, mean±SD) | |
| ADAS11 | 9.08 ± 4.22 |
| ADAS13 | 14.55 ± 6.41 |
| CDRSB | 1.48 (0.89) |
| FAQ | 2.73 (3.77) |
| MMSE | 28.11 (1.67) |
| RAVLT immediate | 37.10 (10.85) |
| RAVLT learning | 4.71 (2.52) |
| RAVLT forgetting | 4.63 (2.54) |
| RAVLT % forgetting | 54.94 (31.48) |
| Plasma biomarkers (pg/mL, mean±SD) | |
| Nfl | 37.17 (18.20) |
| P-tau181 | 18.00 (12.24) |
| Lifestyle factors | |
| Alcoholic (%) | 4.0 |
| Smoking (%) | 37.23 |
| Comorbidities | |
| Hypertension (%) | 45.84 |
| Diabetes (%) | 11.07 |
| Cholesterol (%) | 51.07 |
| Depression (%) | 28.61 |
| Obesity (%) | 24.30 |
| Cardiovascular (%) | 67.07 |
| Hearing Problems (%) | 17.53 |
| TBI (%) | 4.62 |
NOTE: Mean and standard deviation (SD) for continuous variables and percentages for categorical variables were computed.
Abbreviations: N-number of subjects. ADAS - Alzheimer’s Disease Assessment Scale; CDRSB - Clinical Dementia Rating scale Sum of Boxes. FAQ - Functional Assessment Questionnaire. MMSE - Mini-Mental State Examination. RAVLT - Rey’s Auditory Verbal Learning Test.