Table 2.

Primary Outcome

Total Daily Maintenance Dose	Early PTS Cumulative Incidence (95% CI)	Early PTS OW-weighted Cumulative Incidence (95% CI)	Death Cumulative Incidence (95% CI)	Death OW-weighted Cumulative Incidence (95% CI)
≤1000 mg/day	0.039 (0.02, 0.075)	0.029 (0.014, 0.062)	0.058 (0.036, 0.093)	0.04 (0.022, 0.075)
1500 mg/day	0.078 (0.044, 0.139)	0.088 (0.049, 0.158)	0.067 (0.035, 0.13)	0.067 (0.031, 0.144)
≥2000 mg/day	0.084 (0.061, 0.118)	0.09 (0.059, 0.137)	0.096 (0.069, 0.133)	0.094 (0.058, 0.153)
Total Daily Maintenance Dose	Early PTS OW-weighted Estimated sHRs (95% CI)	P-value	Death OW-weighted Estimated sHRs (95% CI)	P-value
1500 mg/day vs. ≤1000 mg/day	3.09 (0.44, 21.85)	0.26	1.67 (0.26, 10.96)	0.59
≥2000 mg/day vs. ≤1000 mg/day	3.16 (0.45, 22.25)	0.25	2.39 (0.4, 14.16)	0.34
≥2000 mg/day vs. 1500 mg/day	1.02 (0.27, 3.91)	0.98	1.43 (0.32, 6.33)	0.64

Cumulative incidences were estimated using the Fine-Gray subdistribution hazard models. Subdistribution hazard ratios (sHR) were obtained from the OW-weighted Fine-Gray model.

PTS: Post-traumatic seizures. OW: Overlap weights. sHRs: Subdistribution hazard ratios.