Table 4.
Unweighted Fine-Gray Subdistribution Hazard Model for Cumulative Incidence of Early PTS
| Early PTS | Death | |||
|---|---|---|---|---|
| sHR (95% CI) | P-value | sHR (95% CI) | P-value | |
| Age (1-year increase) | 1.04 (1.02, 1.07) | <0.01 | 1.02 (1, 1.05) | 0.09 |
| AIS head > 31 | 3.65 (1.47, 9.07) | <0.01 | 2.01 (1.02, 3.97) | 0.04 |
| Pre-hospital GCS >102 | 0.42 (0.22, 0.81) | <0.01 | 0.2 (0.1, 0.37) | <0.01 |
| Operative intervention | 3.89 (2.15, 7.03) | <0.01 | 0.64 (0.33, 1.23) | 0.18 |
| Daily dose <=1000 mg/day3 | 0.53 (0.22, 1.28) | 0.16 | 0.89 (0.36, 2.23) | 0.8 |
| Daily dose >=2000 mg/day3 | 1.22 (0.57, 2.58) | 0.61 | 1.22 (0.57, 2.58) | 0.48 |
| Cortical contusion | 1.31 (0.64, 2.68) | 0.46 | 0.85 (0.42, 1.72) | 0.66 |
| Intracranial hemorrhage | 0.61 (0.07, 5.42) | 0.66 | 0.39 (0.15, 0.99) | 0.05 |
| Penetrating head wound | Not included4 | 2.89 (1.17, 7.16) | 0.02 | |
| Depressed skull fracture | 0.46 (0.05, 4.14) | 0.49 | Not included4 | |
| CrCl (1-unit increase) | 1 (0.99, 1.01) | 0.64 | 0.99 (0.98, 1) | 0.16 |
1
AIS head ≤3 used as reference value
2
Pre-hospital GCS ≤10 used as reference value
3
Daily levetiracetam dose of 1500 mg/day used as reference value
4
Variable was not included in the model because of the complete separation of patients.
sHR: Subdistribution hazard ratio. AIS: Abbreviated Injury Scale. GCS: Glasgow Coma Scale. CrCl: Creatinine clearance.