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. 2023 Mar 20;78:100181. doi: 10.1016/j.clinsp.2023.100181

Fig. 3.

Fig 3

Histological assessment of the skin of ulcer specimens from rats at day 14 after therapy. (A) H&E-stained sections (50 µm). (B) IHC of Ki67 in the skin of ulcer specimens (50 µm). (C) IFC of CD31 in the skin of ulcer specimens (500 µm). (D) IFC of LC3B in the skin of ulcer specimens (500 µm). (E) TEM of the skin of ulcer specimens (2 µm). Autophagosomes (arrow) could be seen in MSC-CM and MSCs group but could hardly be found in DM-C group. (F) The thickness of the stratum granulosums of the skin. The thickness of the stratum granulosums of the skin in MSC-CM or MSCs group was thicker than that in DM-C group (*p < 0.05). (G) PI from ki67 in ulcers. PI of MSC-CM or MSCs group was more than that of DM group (*p < 0.05). (H) MOD from CD31 in ulcers. MOD from CD31 of MSC-CM or MSCs group was higher than that of DM group (*p < 0.05). (I) MOD from LC3B in ulcers. MOD from LC3B of MSC-CM or MSCs group was higher than that of DM group (*p < 0.05). (J) IL-1β levels in ulcers. IL-1β level in ulcers of MSC-CM or MSCs group was lower than that of DM-C group (*p < 0.05).